Divi's Laboratories was established in 1990 as Divi's Research Centre. The company initially started developing commercial processes for the manufacturing of APIs and intermediates. Divi's Research Centre changed its name to Divi's Laboratories Limited in 1994 to signal its intent to enter the API and intermediates manufacturing industry. Following this, the company established its first Manufacturing facility in 1995 at Choutuppal, Telangana. In 2002, the company's second manufacturing facility commenced operations at Chippada near Visakhapatnam.The company went public with its initial public offering on 17 February 2003. In 2010, the company established a research centre in Hyderabad.
