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Halozyme Therapeutics was founded by Howard Birndorf and Harvey Berger in 1998. The company was established to develop proprietary technologies to increase the performance of biologic and small-molecule drugs in the pharmaceutical and biotech markets. Since its inception, Halozyme has developed a range of proprietary technologies, including Enhanze®, its rHuPH20 development platform, and Accent® delivery and solubility technology.