SpringWorks Therapeutics

SpringWorks Therapeutics, Inc. acquires, develops, and commercializes medicines for underserved patient populations suffering from rare diseases and cancer. Its lead product candidate is nirogacestat, an oral small molecule gamma secretase inhibitor that is in Phase III clinical trial for the treatment of desmoid tumors. The company is also developing mirdametinib, an oral small molecule MEK inhibitor that is in Phase 2b clinical trials for the treatment of neurofibromatosis type 1-associated plexiform neurofibromas, as well as Phase 1/2a clinical trial for the treatment of NF1-PN; mirdametinib + lifirafenib, a combination therapy that is in Phase 1b/2 clinical trial in patients with advanced or refractory solid tumors; and mirdametinib in monotherapy and combination approaches to treat solid tumors. In addition, it develops BGB-3245, an oral selective small molecule inhibitor of monomeric and dimeric forms of activating BRAF mutations, which is in Phase I clinical trial. The company has collaborations with BeiGene, Ltd., GlaxoSmithKline LLC, and Allogene to develop combination approaches with nirogacestat and mirdametinib; and license agreements with Pfizer Inc. for nirogacestat and mirdametinib. It also has a license agreement with Katholieke Universiteit Leuven and the Flanders Institute for Biotechnology for a portfolio of novel small molecule inhibitors of the TEA Domain; and Dana-Farber Cancer Institute for a portfolio of novel small molecule inhibitors of Epidermal Growth Factor Receptor. In addition, the company has clinical collaboration agreement with Janssen Biotech, Inc., Precision BioSciences, Inc., Seagen Inc., and AbbVie, Inc. SpringWorks Therapeutics, Inc. was founded in 2017 and is headquartered in Stamford, Connecticut.

SpringWorks Therapeutics was established in 2016 by Third Rock Ventures to discover, develop and bring meaningful therapies to those with rare diseases and cancer. The company is led by a team of experienced and innovative biotechnology professionals, many of whom have held leadership roles at leading healthcare companies. The company's development pipeline contains numerous compounds, many of which are in mid- to late-stage clinical development.

Our mission is to create treatments that will bring radical improvements in the lives of those with rare diseases, cancers, and other challenging diseases.

It is our vision to build a different kind of healthcare company – one that puts people first, creates treatments that provide meaningful impact on those affected, and develops and brings treatments to those in need.

Our mission is to create treatments that will bring radical improvements in the lives of those with rare diseases, cancers, and other challenging diseases.

SpringWorks Therapeutics

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SpringWorks Therapeutics

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