Summary
Cue Biopharma, Inc., a clinical-stage biopharmaceutical company, develops biologic drugs for the selective modulation of the human immune system to treat a range of cancers, chronic infectious diseases, and autoimmune disorders. Its lead drug candidate is CUE-101, a fusion protein biologic that is in Phase 1b clinical trial designed to target and activate antigen-specific T cells for human papilloma virus-driven cancers. The company offers CUE-102, a fusion protein biologic to target and activate antigen-specific T cells to fight cancers; CUE-103 a CUE-100 series Immuno-STAT targeting the KRAS G12V mutation, including colorectal carcinoma, lung cancer, and pancreatic cancer; CUE-200 that focuses on cell surface receptors, including CD80 and/or 4-1BBL to address T cell exhaustion associated with chronic infections; and CUE-300 and CUE-400 framework to target various autoimmune diseases. Cue Biopharma, Inc. has collaboration agreements with Merck Sharp & Dohme Corp. for the research and development of its proprietary biologics that target various autoimmune disease indications; LG Chem Life Sciences for the development of Immuno-STATs focused on the field of oncology; and Albert Einstein College of Medicine. The company was formerly known as Imagen Biopharma, Inc. and changed its name to Cue Biopharma, Inc. in October 2016. Cue Biopharma, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts.
History
The company was founded in 2017 by Noubar Afeyan, a MIT professor, serial entrepreneur, and one of the world’s leading innovators in life sciences and technology. Cue Biopharma’s platform uses a proprietary technology to control the release of biologic drugs that are tailored to a patient’s specific needs. This enables Cue Biopharma to develop therapies with enhanced efficacy and improved safety profile compared to existing treatments.
Mission
Cue Biopharma’s mission is to develop therapies with potential to make a meaningful difference in the lives of people living with serious diseases, such as autoimmune and cancer.
Vision
Cue Biopharma’s vision is to transform treatments for chronic diseases through the use of smart combination therapies based on precision drug delivery.
Key Team
Dr. Ronald D. Seidel III, Ph.D. (Co-Founder)
Dr. Rodolfo J. Chaparro (Co-Founder & Sr. Advisor)
George B. Zavoico Ph.D. (VP of Investor Relations & Corp. Devel.)
Dr. Steven C. Almo (Co-Founder and Chairman of Scientific & Clinical Advisory Board)
Mr. Colin G. Sandercock J.D., MSE (Sr. VP, Gen. Counsel & Sec.)
Dr. Kenneth J. Pienta M.D. (Acting Chief Medical Officer)
Dr. Matteo Levisetti M.D. (Sr. VP of Clinical Devel.)
Recognition and Awards
Cue Biopharma has been recognized in numerous industry awards, including the Politico 50, Pharmaceutical Executive Magazine’s Emerging Companies to Watch list and Fierce Biotech's Fierce 15.
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