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Neurocrine Biosciences

Neurocrine Biosciences
Leadership team

Dr. Kevin C. Gorman Ph.D. (CEO & Director)

Mr. Matthew C. Abernethy (Chief Financial Officer)

Dr. Jude Onyia Ph.D. (Chief Scientific Officer)

Products/ Services
Biotechnology, Health Care, Pharmaceutical
Number of Employees
1,000 - 20,000
Headquarters
San Diego, California, United States
Established
1992
Company Registration
SEC CIK number: 0000914475
Net Income
20M - 100M
Revenue
Above - 1B
Social Media
Overview
Location
Summary
Neurocrine Biosciences, Inc. discovers, develops, and markets pharmaceuticals for neurological, endocrine, and psychiatric disorders. The company's portfolio includes treatments for tardive dyskinesia, Parkinson's disease, endometriosis, and uterine fibroids, as well as clinical programs in various therapeutic areas. Its lead asset is INGREZZA, a VMAT2 inhibitor for the treatment of tardive dyskinesia. The company's commercial products include ONGENTYS, a catechol-O-methyltransferase inhibitor used as an adjunct therapy to levodopa/DOPA decarboxylase inhibitors for patients with Parkinson's disease; ORILISSA for the management of moderate to severe endometriosis pain in women; and ORIAHNN, a non-surgical oral medication option for the management of heavy menstrual bleeding associated with uterine fibroids in pre-menopausal women. Its product candidates in clinical development include NBI-921352 for treating pediatric patients, as well as adult focal epilepsy indications; and NBI-827104 to treat rare pediatric epilepsy and essential tremor. The company's products in clinical development also comprise NBI-1065845 for the treatment of major depressive disorder; NBI-1065846 for treating anhedonia in major depressive disorder; and NBI-118568 for the treatment of schizophrenia. It has license and collaboration agreements with Heptares Therapeutics Limited; Takeda Pharmaceutical Company Limited; Idorsia Pharmaceuticals Ltd; Xenon Pharmaceuticals Inc.; Voyager Therapeutics, Inc.; BIAL – Portela & Ca, S.A.; Mitsubishi Tanabe Pharma Corporation; and AbbVie Inc. Neurocrine Biosciences, Inc. was incorporated in 1992 and is headquartered in San Diego, California.
History

Neurocrine was founded in San Diego, California, in 1992. The company's academic founders were Wylie Vale of the Salk Institute for Biological Studies, and Lawrence Steinman of Stanford University. The company was backed by Avalon Ventures among others.In 1995, the company collaborated with Belgium-based Janssen Pharmaceutica N.V. to develop treatments for psychiatric disorders utilizing corticotropin releasing factor antagonists, a class of compounds to treat psychiatric, neurological and gastrointestinal diseases including anxiety, depression and irritable bowel syndrome. The company underwent an IPO in May 1996, listing on the NASDAQ exchange under the symbol NBIX and raising $34.2 million.In October 1996, Eli Lilly and Company agreed to pay Neurocrine $74 million over five years to develop drugs for obesity and Alzheimer's disease based on its research of CRF-binding protein-ligand inhibitors.In July 2001, Neurocrine and GlaxoSmithKline entered into a worldwide research, development and commercialization agreement, including a collaborative research program for up to five years to identify and develop CRF-R antagonist compounds. The collaboration also included worldwide development and commercialization of NBI-34041 as well as potential backup candidates resulting from the research program. Neurocrine received upfront fees and early milestone payments totaling $25.5 million.In December 2002, Neurocrine reached an agreement with Pfizer for the rights to its experimental insomnia drug, indiplon. The deal paid Neurocrine $100 million initially with a possible $300 million more if the drug met regulatory and sales goals. In May 2006, the FDA issued a non-approvable letter for a modified-release 15 mg formulation of indiplon and an approvable letter with stipulations for 5 mg and 10 mg immediate-release formulations. As a result, Pfizer terminated its agreement with Neurocrine. Following a resubmission of the 5 mg and 10 mg formulations in December 2007, Neurocrine's new drug application was deemed 'approvable' but the FDA requested additional studies. The company discontinued development of the drug in the United States. In 2007, Neurocrine partnered with Dainippon Sumitomo Pharma to develop and commercialize indiplon in Japan. The deal paid Neurocrine $20 million up front with the ability to receive milestone payments and royalties based on the commercialization of indiplon in Japan.Kevin Gorman replaced Gary Lyons as CEO of the company in January 2008. Lyons was CEO and president of the company since its founding and maintained a role on the company's board of directors.On June 16, 2010, Neurocrine agreed to a deal with AbbVie Inc. worth up to $575 million with Neurocrine granting AbbVie the worldwide rights to develop and commercialize elagolix, an oral gonadotropin-releasing hormone antagonist to treat endometriosis and uterine fibroids. The deal paid Neurocrine $75 million up front.In April 2017, the FDA approved valbenazine for the treatment of TD. At the time of approval, it was the first and only drug approved for adults with TD. Neurocrine is also studying valbenazine in clinical trials for the treatment of Tourette Syndrome. In October 2017, Neurocrine announced that it had been granted orphan drug designation status from the FDA for valbenazine for the treatment of pediatric patients with Tourette syndrome.In February 2017, Neurocrine announced an exclusive licensing agreement for the development and commercialization of the Parkinson's disease drug, opicapone, in North America with the Portugal-based pharmaceutical company Bial. As part of the agreement, Neurocrine provided an upfront payment of $30 million and agreed to fund development activities for FDA approval in the United States. Bial is eligible to receive additional milestone payments of up to $115 million and a percentage of net sales.In September 2017, AbbVie submitted a NDA to the FDA for elagolix for the management of endometriosis and associated pain. The submission was supported by two similar Phase 3 clinical studies involving 1,700 women. In October 2017, AbbVie and Neurocrine announced that the FDA granted priority review for the elagolix NDA. A final regulatory decision on the drug will come during the third quarter of 2018. The companies are also developing elagolix for the treatment of uterine fibroids which is in Phase III development.

Mission
At Neurocrine, our mission is to be a leader in precise and transformative neurologic and endocrine therapies that bring deep and lasting benefit to the people who have these conditions.
Vision
We envision a world in which the dignity, safety and quality of life of patients and their families are not compromised by chronic nervous system, endocrine, and behavioral disorders.
Key Team

Mr. Eric S. Benevich (Chief Commercial Officer)

Dr. Eiry Wyn Roberts M.D. (Chief Medical Officer)

Dr. Dimitri E. Grigoriadis (Chief Research Officer)

Mr. Darin M. Lippoldt (Chief Legal Officer & Corp. Sec.)

Jane Sorensen (Head of Investor Relations)

Mr. Kyle W. Gano (Chief Bus. Devel. and Strategy Officer)

Ms. Julie S. Cooke (Chief HR Officer)

Recognition and Awards
Neurocrine Biosciences has won numerous awards, including four distinction awards from The Women’s Admiration Awards and four Medtech Breakthrough awards. They have also been recognized with numerous awards from the San Diego Business Journal.
References
Neurocrine Biosciences
Leadership team

Dr. Kevin C. Gorman Ph.D. (CEO & Director)

Mr. Matthew C. Abernethy (Chief Financial Officer)

Dr. Jude Onyia Ph.D. (Chief Scientific Officer)

Products/ Services
Biotechnology, Health Care, Pharmaceutical
Number of Employees
1,000 - 20,000
Headquarters
San Diego, California, United States
Established
1992
Company Registration
SEC CIK number: 0000914475
Net Income
20M - 100M
Revenue
Above - 1B
Social Media