Summary
Silence Therapeutics plc, a biotechnology company, focuses on the discovery and development of novel ribonucleic acid (RNA) therapeutics in hematology, cardiovascular, and other rare and metabolic indications. The company's platform includes mRNAi GalNAc Oligonucleotide Discovery platform designed to accurately target specific disease-associated genes in the liver. It designs short interfering RNA molecules to harness the body's natural mechanism of RNA interference, and degrading messenger RNA molecules that encode specific targeted disease-associated proteins in a cell. The company is developing various product candidates, including SLN360, which is Phase I clinical trials for the treatment of cardiovascular disease with high lipoprotein; SLN124 that is in Phase I clinical trials for the treatment of non-transfusion dependent thalassemia, and Phase I clinical trials for the treatment of myelodysplastic syndrome; and SLN124 for the treatment of polycythemia vera. It has collaboration agreements with AstraZeneca PLC to discover, develop, and commercialize small interfering RNA therapeutics for the treatment of cardiovascular, renal, metabolic, and respiratory diseases; and Mallinckrodt Pharma IP Trading DAC to develop and commercialize RNAi drug targets designed to silence the complement cascade in complement-mediated disorders. The company also has a collaboration with Hansoh Pharmaceutical Group Company Limited to develop siRNAs for three undisclosed targets leveraging Silence's mRNAi GOLD platform. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc is headquartered in London, the United Kingdom.
History
Founded in 2011, Silence Therapeutics has made significant advances in the field of RNAi therapeutics. We have integrated drug discovery and development capabilities, with a team of scientists who design, develop and research novel drug candidates using our proprietary, target- specificity technology. Our achievement has been recognized by several prestigious awards and our therapies are being tested in clinical trials all over the world.
Mission
At Silence Therapeutics, we are committed to developing innovative RNAi therapeutics that can address previously untreatable and under-served disease areas, transforming treatments and patient outcomes.
Vision
Our mission is to be the leading provider of innovative and effective RNAi therapeutics, restoring and improving health and quality of life for those suffering from severe, serious and life-threatening diseases
Key Team
Ms. Gem Gokmen Hopkins (Head of IR & Corp. Communications)
Dr. John Strafford Ph.D. (Sr. VP of Bus. Devel., Alliance Management & New Product Devel.)
Mr. Jørgen Wittendorff (Sr. VP & Head of Manufacturing)
Dr. Barbara A. Ruskin J.D., Ph.D. (Sr. VP and Chief Intellectual Property & Innovation Officer)
Dr. Eric Floyd Ph.D. (Sr. VP of Regulatory Affairs & Quality Assurance)
Dr. Marie Wikstrom Lindholm Ph.D. (Sr. VP & Head of Molecular Design)
Recognition and Awards
Silence Therapeutics is proud to have been recognized for our groundbreaking work in the RNAi therapeutics field. We have won numerous awards from the Royal Society of Chemistry, the European Pharma Resources Awards, the Great British Business Awards, and been named as a top ten company for regenerative medicine.
References
United Kingdom 