1

Swedish Orphan Biovitrum

#1721

Rank

$9.81B

Marketcap

SE Sweden

Country

Swedish Orphan Biovitrum
Leadership team

Dr. Guido Oelkers (CEO & Pres)

Dr. Anders Ullman M.D., Ph.D. (Head of R&D & Medical Affairs and Chief Medical Officer)

Mr. Henrik Stenqvist (Chief Financial Officer)

Products/ Services
Biotechnology, Genetics
Number of Employees
1,000 - 20,000
Headquarters
Solna, Stockholms Lan, Sweden
Established
1988
Net Income
100M - 500M
Revenue
Above - 1B
Traded as
SOBI.ST
Overview
Location
Summary
Swedish Orphan Biovitrum AB (publ), an integrated biotechnology company, researches, develops, manufactures, and sells pharmaceuticals in the therapeutic areas of haematology, immunology, and genetic and metabolic diseases in Europe, North America, and internationally. It offers Alprolix for haemophilia B; Doptelet treatment of thrombocytopenia; Elocta for haemophilia A; Gamifant for hemophagocytic lymphohistiocytosis(HLH); Kineret for cryopyrin associated periodic syndrome, rheumatoid arthritis, and still's disease; Orfadin to treat hereditary tyrosinaemia type-1; and Synagis for serious lower respiratory tract infection. The company It also provides other products, such as Akynzeo, Aloxi, Ammonul, Betapred, Caphosol, Fibclot, IVheBex, and Willfact. In addition, it develops drug substance for ReFacto AF/Xyntha for Pfizer; BIVV001 for haemophilia A; and Nirsevimab for respiratory syncytial virus. The company has a strategic collaboration with Apellis Pharmaceuticals Inc. to develop pegcetacoplan for the treatment of multiple rare diseases, including paroxysmal nocturnal hemoglobinuria. Swedish Orphan Biovitrum AB (publ) is headquartered in Solna, Sweden.
History

Sobi traces its origins to a subsidiary of Kärnbolaget Aktiebolag Biokemisk Industri in the 1930s, which changed its name to Kabi in 1951 and merged with Vitrum to become KabiVitrum in the 1970s.Sobi has been involved in the process development and manufacturing of recombinant protein drugs since the technology was first developed around 30 years ago, then as part of KabiVitrum.

Biovitrum was formed in 2001 through the merger of several units of Pharmacia and spun off to a consortium of investors led by Nordic Capital and MPM Capital Funds. Operations included a research unit focused on metabolic diseases, a process development unit for protein drugs and a plasma product operation. In 2002 Sobi sold its plasma operation to Octapharma as part of efforts to concentrate operations on protein-based and small molecular drugs.

In 2004, Biovitrum started to manufacture the active protein component for Wyeth’s ReFacto® and ReFacto/Xyntha® drugs for treatment of hemophilia, and marketing of specialty pharmaceuticals was initiated in the Nordic region. In 2005, the research and development portfolio was expanded through the acquisition of Arexis, a Swedish biotech company, and the following year a partnership was formed with Syntonix to jointly develop a drug for hemophilia B, a long-lasting recombinant factor IX Fc fusion protein candidate, rFIXFc. This partnership was extended the following year to also include the development of a long-lasting recombinant factor VIII Fc fusion protein candidate, rFVIIIFc, for the treatment of hemophilia A.

In 2008, an agreement with Amgen regarding the acquisition of the products Kepivance and Stemgen as well as a global license for Kineret was signed

In 2009, Sobi and partner Biogen Idec took the decision to enter final registration studies for the recombinant factor FIXFc. The company also received positive data regarding its Kiobrina phase II program, an investigational enzyme replacement therapy to improve growth in preterm infants who receive pasteurized breast milk or infant formula.

In 2010, Biovitrum acquired Swedish Orphan International Holding AB, a pioneer in orphan drugs, and Swedish Orphan Biovitrum AB was formed. In addition, the decisions to advance both hemophilia projects as well as Kiobrina into phase III were taken. The following year the first patient was enrolled in the phase 3 study for Kiobrina and data from the rFVIIIFc hemophilia phase I/II study were presented showing an approximately 1.7-fold increase in half-life compared with Advate. The company also established a US subsidiary.In 2012 the supply agreement with Pfizer for ReFacto/Xyntha was extended until 2020 in addition to the agreement to return the co-promotion rights for the Nordic region for ReFacto to Pfizer for a payment of USD 47.4 M. The same year, the Sobi and partner Biogen Idec initiated global pediatric clinical trials of their long-lasting hemophilia A and B product candidates.

Guido Oelkers was appointed President and CEO in May 2017, succeeding Geoffrey McDonough. Oelkers had previously been CEO of BSN Medical.

Mission
Our mission is to make a world of difference to patients and families touched by rare diseases.
Vision
Our vision is to continue to be the leading global specialty care player with a focus on rare disease.
Key Team

Ms. Christine Wesstrom (Head of Technical Operations)

Mr. Thomas Kudsk Larsen (Head of Communication & Investor Relations)

Mr. Torbjörn Hallberg (Gen. Counsel and Head of Legal Affairs & HR)

Mr. Daniel Rankin (Head of Strategy & Corp. Devel.)

Mr. Philip Wood (Head of Haematology)

Ms. Konstantina Karampela (Sr. Director of European Commercial Operations (Specialty Care and Partner Products))

Pablo de Mora (Head of Global Marketing & Access)

Recognition and Awards
Sobi has earned awards for innovation, sustainability and corporate social responsibility, among others. In 2011, we were awarded the Stockholm Innovation Award, and in 2013 the European Business Awards. In 2017, we were awarded the Specialty Care Company of the Year award by the Rare Diseases Group.
References
Swedish Orphan Biovitrum
Leadership team

Dr. Guido Oelkers (CEO & Pres)

Dr. Anders Ullman M.D., Ph.D. (Head of R&D & Medical Affairs and Chief Medical Officer)

Mr. Henrik Stenqvist (Chief Financial Officer)

Products/ Services
Biotechnology, Genetics
Number of Employees
1,000 - 20,000
Headquarters
Solna, Stockholms Lan, Sweden
Established
1988
Net Income
100M - 500M
Revenue
Above - 1B
Traded as
SOBI.ST