U.S. Department of Energy Announces 24-Organisation AI Collaboration for the Genesis Mission

The U.S. Department of Energy announces partnerships with 24 organisations to advance the Genesis Mission, a national AI initiative aligned with President Trump’s AI Action Plan. The mission unites government, industry, and 17 national laboratories to accelerate scientific discovery, strengthen national security, and drive innovation in energy, manufacturing, quantum computing, and advanced research.

The U.S. Department of Energy (DOE) announces collaboration agreements with 24 organisations to advance the Genesis Mission, a national initiative designed to use artificial intelligence (AI) to accelerate scientific discovery, strengthen national security, and drive innovation across the energy sector and beyond. The announcement marks a significant step in building a coordinated public-private AI ecosystem to support large-scale research and development across the United States.

The Genesis Mission aligns with President Trump’s Executive Order Removing Barriers to American Leadership in Artificial Intelligence and supports the administration’s America’s AI Action Plan, released earlier this year. The initiative focuses on removing barriers to innovation, reducing dependence on foreign adversaries, and expanding the reach of America’s scientific infrastructure through advanced AI systems.

Public-Private Partnerships to Build National AI Infrastructure

The announcement follows a White House meeting involving industry leaders, U.S. Secretary of Energy Chris Wright, DOE Under Secretary for Science and Genesis Mission Director Dr. Darío Gil, and Director of the White House Office of Science and Technology Policy (OSTP) Michael Kratsios. The meeting formally launches a new phase of public-private partnerships aimed at securing scalable AI infrastructure for scientific research and national priorities.

These partnerships are structured to support architecture-agnostic AI systems, ensuring flexibility and broad usability across federal agencies, national laboratories, academia, and industry.

“Today’s announcement of 24 new research partnerships is only the beginning, as we deliver on President Trump’s mandate to bring the entire scientific community, including companies, universities, non-profits, and Federal agencies, into the Genesis Mission,” said Assistant to the President and OSTP Director Michael Kratsios. 

“Harnessing cutting-edge AI for science will dramatically increase the productivity of American scientists and researchers. The Genesis Mission will help America’s scientists automate experiment design, accelerate simulations, and generate predictive models that will lead to breakthroughs in energy, manufacturing, drug discovery, and beyond.”

Advancing Science Through AI-Driven Research

The Genesis Mission brings together 17 national laboratories and approximately 40,000 researchers, with the goal of accelerating progress in fields such as nuclear energy, quantum computing, advanced manufacturing, and materials science. AI tools developed and deployed under the initiative aim to automate experimental workflows, enhance simulation accuracy, and generate predictive models at unprecedented speed and scale.

DOE Under Secretary for Science and Genesis Mission Director Dr. Darío Gil emphasises the mission’s role in strengthening the U.S. research ecosystem.

“Thanks to President Trump’s leadership, the Genesis Mission will be transformative for our country, uniting industry, academia, and our National Labs to deliver powerful and impactful scientific discovery and innovation,” said Dr. Gil. 

“These agreements help advance President Trump’s Executive Order to build the national AI platform for scientific discovery and uplift the entire U.S. R&D ecosystem.”

Industry Participation and Technology Contributions

The 24 organisations signing memorandums of understanding (MOUs) either responded to DOE requests for information (RFIs) or are already engaged in active projects with DOE and the National Laboratories. Their participation reflects a broad cross-section of the AI ecosystem, including frontier AI labs, semiconductor manufacturers, cloud infrastructure providers, systems integrators, and research organisations.

The organisations include:

Accenture, AMD, Anthropic, Armada, Amazon Web Services, Cerebras, CoreWeave, Dell, DrivenData, Google, Groq, Hewlett Packard Enterprise, IBM, Intel, Microsoft, NVIDIA, OpenAI, Oracle, Periodic Labs, Palantir, Project Prometheus, Radical AI, xAI, and XPRIZE.

Several partners have already outlined specific contributions. Google DeepMind provides early access to AI tools for laboratory scientists, including its AI co-scientist agent, the AlphaEvolve coding system, and the AlphaGenome DNA model. Amazon Web Services commits up to $50 billion in government AI infrastructure investment, while OpenAI deploys models on Los Alamos National Laboratory’s Venado supercomputer. Additional support comes from organisations such as Microsoft, Palantir, AMD, Oracle, Cerebras, and CoreWeave.

Open Calls for Future Collaborators

The DOE confirms that collaboration under the Genesis Mission remains open. The department plans future convenings with private industry, academic institutions, and philanthropic organisations to expand the network of qualified partners.

Two RFIs are currently open for submissions. The “Partnerships for Transformational Artificial Intelligence Models” RFI remains open until 14 January 2026, while the “Transformational AI Capabilities for National Security” RFI is open until 23 January 2026.

Through the Genesis Mission, the DOE positions AI as a foundational capability for scientific progress, national security, and energy innovation, bringing together government, industry, and research institutions to advance discovery at national scale.

Why It Matters

The Genesis Mission signals a shift in how the United States approaches large-scale scientific research and national infrastructure. By combining AI capabilities from leading technology providers with the expertise of national laboratories and academic institutions, the initiative aims to shorten research cycles, reduce costs, and improve the reliability of scientific outcomes. 

Its focus on architecture-agnostic systems limits vendor dependence while strengthening resilience and security. The mission also positions AI as a core tool for national competitiveness, supporting long-term progress in energy, manufacturing, quantum computing, and security-critical research.